APPIRED III study is getting well on its way with 9 centres started with including patients. These centres are Singapore NUH, CZE Eindhoven, Jessa, Hasselt, UniMed Wien Vienna, Almazov Heart Centre St Petersburg and IJN Kuala Lumpur. Recently Monash Melbourne, AZM Middelares, Gent, MUMC Maastricht were added. Four additional centers in St Petersburg and Kazan are readied up to enrol patients. Up to 4 other sites await either local or governmental approval